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Aug 20, 2020 · Our results highlight the importance of flexible linkers in regulating multidomain chromatin binding proteins and point to divergent evolution ...
Sep 28, 2020 · Pyruvate kinase muscle isoform 2 (PKM2) is a key glycolytic enzyme and transcriptional coactivator and is critical for tumor metabolism.
Missing: Genomics Consortium|
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Jul 1, 2020 · We show that insertion of nine amino acids in a linker region connecting the different TTD and PHD histone modification-binding domains causes ...
Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation. Filippakopoulos P, Kofler M, Hantschel O, Gish GD, ...
/ Structural Genomics Consortium (SGC). Citation, Journal: to be published. Title: Activator-Bound Structures of Human Pyruvate Kinase M2 Authors: Hong, B ...
May 25, 2023 · An entropy switch controls the Aurora B autoactivation process through two distinct kinetic steps of phosphorylation.
Nov 25, 2020 · PGK is usually a monomeric enzyme of about 45 kDa that catalyses one of the two ATP-producing reactions in the glycolytic pathway, through the ...
Sep 14, 2010 · We have determined the crystal structure of the PK1 enzyme from T. gondii, with the B domain in the open and closed conformations. We have also ...
Jun 16, 2000 · The enzyme must be equipped with structural components that are able to transmit the allosteric signal over such a long distance across the two ...
Jun 24, 2011 · Here we show that PKM2 is acetylated on lysine 305 and that this acetylation is stimulated by high glucose concentration. PKM2 K305 acetylation ...